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Drug Safety Testing

Drug induced Hepatotoxicity Testing

update time：2023-07-06 09:18:50Number of clicks：376

The NAC-Organ technology can assemble primary liver cells in proportion into 3D cultured micro liver tissue (NAC Liver) in just 24 hours, significantly reducing the differentiation time of liver parenchymal cells and maintaining stable liver function for more than 30 days in vitro.

The NAC-Organ technology can assemble primary liver cells into a 3D cultured micro-liver tissue (NAC-Liver) within 24 hours, significantly reducing the differentiation time of hepatocytes. This allows the stable maintenance of liver functions in vitro over 30 days

NAC-Liver can better maintain liver physiological function and maintain high levels of albumin and urea secretion compared to 2D cultured liver cells NAC-Liver can maintain stable expression of the hepatitis B virus receptor (NTCP)

NAC-Liver Drug induced Hepatotoxicity Testing

The 3D NAC-Liver model can be applied to drug-induced hepatotoxicity assessment, drug metabolism research, antiviral drug development, and liver disease mechanism studies

During long-term in vitro cultivation, NAC-Liver maintains stable drug-metabolizing enzyme activity. The correlation between toxicity testing using NAC-Liver and the FDA's classification of drug-induced liver toxicity exceeds 70% 2D sandwich model 51.00% 69.00% 59.40% 61.00% Insphero spheriod Corning spheriod NAC-liver 72.15% Chemically defined spheroid Reported predictivesensitivity
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